PM20D1 Reveals How Ancient Peptidases Evolve New Functions
A research explainer on how the enzyme PM20D1 evolved from an ancestral peptidase into a lipid-signaling enzyme that regulates thermogenesis in mammals.
ClaudeArtifact
#research
40 entries with this tag.
Power System Simulator Market Report
A syndicated market-research report on power system simulator software, covering market size, growth drivers, segments, and competitive landscape through 2032.
ClaudeArtifact
Resolving Prediction-Market Questions About Congress
The user corrects the assistant's sloppy reading of a prediction market twice, forcing precise, cited answers about the 118th Congress's real 2024 actions.
Claude
Tiering twelve VDR-activating supplements for glaucoma evidence
A tiered evidence review of glaucoma supplements, separating the two backed by real human trial data from a long list resting on little more than mechanism.
Claude
Underexplored Disciplines in Catastrophic AI Risk Research
A survey essay covering seventeen academic fields, from primatology to classics, that are rarely applied to AI extinction and power-concentration risk research.
ClaudeArtifact
Untangling How BLIP-2 Matches Images to Text Queries
A patient back-and-forth unpacks how BLIP-2's joint image-text embeddings work, then traces the idea's evolution through 2024 vision-language research.
Claude
What scientific publishing looks like after AI peer review
Asked to imagine research without flattery, Claude sketches a future where papers become living objects and reputation attaches to claims, not authors.
Claude
What Survives When Ketanserin Blocks a Psilocybin Trip
A pharmacology deep dive into which effects of psilocybin persist under 5-HT2A blockade, moving from mechanism to the actual human trial data.
ClaudeCW
Which cancer drugs work best against EGFR-amplified tumors
A rapid-fire database query pulls together every FDA-approved EGFR inhibitor and the clinical trial evidence for which cancers actually respond to them.
Claude
Why compressing Du Fu's most famous poem misreads it
Claude delivers a scholarly takedown of five compressed English versions of Du Fu's "Spring Prospect," arguing that chasing syllable count betrays the poem.
Claude★ Editor’s pick
A proof of Erdos Problem 691, reviewed until it holds
Claude reviews drafts of a proof for Erdos Problem 691 on density of multiples, catches a real logical gap, and judges whether outside critiques are valid.
Claude★ Editor’s pick
Cross-Examining the Top Satoshi Nakamoto Suspects
The user has Claude build a rigorous case for and against each leading Satoshi Nakamoto candidate, then prunes the list using hard contradicting facts.
Claude
Do 80s chart hits get more radio replay today than recent hits
The user asks Claude to test whether classic chart hits get more radio replay years later than today's hits, weighing methods, data limits, and sources.
Claude
How ReAct Agents Interleave Reasoning and Acting
Claude explains the ReAct reasoning-acting loop, shares the source paper, and details how grounding fixes chain-of-thought hallucination, citing benchmarks.
Claude
The hidden statistical trap in a $100k tutoring mega-study
The user shares an announcement for a Netflix-funded tutoring study and asks Claude its biggest validity flaw; the reply zeroes in on outcome-measure bias.
Claude
Turning 'AI's favorite meal' into a rigorous LLM attractor study
The user builds a rigorous eval from a whimsical question about AI's ideal meal, tracking recurring food patterns like ramen and mango across model tiers.
Claude★ Editor’s pick